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Type 1 Diabetes - TrialNet e-news - Fall 2012


Children climbing

Teplizumab Prevention Study Now Open to Younger Children
TrialNet’s Teplizumab Prevention Study is now enrolling children as young as 8 years old. Previously, the study was limited to those ages 16 to 45.

The study will determine whether the drug Teplizumab can stop or slow down the disease process in individuals with the highest risk of developing type 1 diabetes. Those eligible for the study have a 75 percent or more chance of developing the disease in the next five to six years. In earlier studies, Teplizumab has shown promise in preserving insulin production in people newly diagnosed with type 1 diabetes. Go



Natural History Study of the Development of Type 1 Diabetes: Screening and observing relatives of people with type 1 diabetes to learn more about how the disease occurs.

Oral Insulin for Prevention of Type 1 Diabetes Study
: Testing whether a daily oral insulin capsule can prevent or delay type 1 diabetes in at-risk relatives of people with the disease.

Teplizumab Anti-CD3 Prevention Study: Testing whether Teplizumab can stop or slow down the autoimmune reaction that is destroying beta cells in people who are at high risk of developing type 1 diabetes.


Dillon Berg

From Coast to Coast, Kids Join Teplizumab Prevention Study to Help Find Answers

Fourteen-year-old Dillon Berg, of Kent, Washington, is participating in the Teplizumab Prevention Study at Benaroya Research Institute in Seattle. Because brother Aiden, 11, and sister Heather, 18, were diagnosed with the disease years earlier, mother Toni had been especially interested in getting Dillon screened by TrialNet.

The Bergs learned about TrialNet screening at the American Diabetes Association Expo in Seattle. When Dillon was first screened, he showed no markers for the disease. He continued getting yearly blood draws until antibodies appeared, signaling an increased risk for diabetes. Then he was tested every 6 months. When the number of antibodies rose, the Bergs were contacted about the Teplizumab Prevention Study.


Zach Clinton and his parents

Ten-year-old Zach Clinton of Gastonia, North Carolina, was first screened by TrialNet at a JDRF event at a North Carolina amusement park. When his results signaled an increased risk of developing type 1 diabetes, mother Ziana said their first reaction was, “Kid number two—here we go.” Their son Ryan, age 12, was diagnosed three years earlier. He was the one who talked Zach into being screened.

The Clintons went to their closest TrialNet physician, Dr. Bryce Nelson in Greenville, South Carolina, for additional testing. There, they learned Zach was eligible for the Teplizumab Prevention Study at Vanderbilt University Medical Center in Nashville, Tennessee. Go


Stop Diabetes

November is American Diabetes Month 
During American Diabetes Month 2012, the American Diabetes Association encourages Americans to share “A Day in the Life of Diabetes” by uploading a personal image on their Facebook page to show what the daily life of diabetes means to them. For every photo/image uploaded, CVS/pharmacy will donate $1.00 to the American Diabetes Association, up to $25,000.

Learn how you can share your personal image and story during American Diabetes Month by visiting:

World Diabetes Day

November 14 is World Diabetes Day
World Diabetes Day was created in 1991 by the International Diabetes Federation and the World Health Organization in response to growing concerns about the escalating health threat that diabetes now poses. The campaign draws attention to issues of paramount importance to the diabetes world and keeps diabetes firmly in the public spotlight. The campaign features a new theme each year to address issues facing the global diabetes community. Go

TrialNet risk screening available virtually anywhere
TrialNet risk screening is available at nearly 200 sites across the United States or anywhere via mail. You can find a TrialNet screening location by completing the online screener. To request a test kit by mail, just contact one of our clinical centers listed here. The test kit can be taken to a local doctor’s office or lab to collect a blood sample for analysis by TrialNet’s lab. Risk screening is available at no charge to those who are:
  1. Age 45 and younger who have a parent, sibling, or child with type 1 diabetes, or
  2. Age 20 and younger who have a niece, nephew, aunt, uncle, grandparent, half-sibling or cousin with type 1 diabetes.

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