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Information for Researchers

Ancillary Studies

TrialNet recognizes the importance of ancillary studies in the overall mission to better understand thePathway to Prevention (Natural History) of type 1 diabetes, to devise means to prolong the honeymoon phase in subjects with new onset disease, and to prevent diabetes altogether. Ancillary studies that complement the objectives and thereby enhance the value of TrialNet studies are strongly encouraged.

Ancillary studies will be evaluated with careful consideration for their potential impact on the objectives and performance of TrialNet studies. Further, ancillary studies must not interfere with the continued interest and participation of the study subjects and investigators. To protect the interests of TrialNet, each ancillary study must be reviewed and approved by the Ancillary Studies Committee before its initiation. If an ancillary study is considered highly worthy by the Ancillary Studies Committee, but may cause deviation in the study protocol, or may interfere with the subjects’ interest or participation in TrialNet, then the study must be additionally reviewed and approved by the TrialNet Steering Committee before formal approval is granted. All approved ancillary studies will be reviewed yearly to evaluate their progress, and impact on TrialNet as a whole.

TrialNet welcomes the submission of ancillary studies as an adjunct to ongoing protocols.

Current Funding Opportunities

NIDDK active funding opportunities:

  • PAR 12-265: Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) has been published, see http://grants.nih.gov/grants/guide/pa-files/PAR-12-265.html.

  • PAR-13-228: Biomarkers for Diabetes, Digestive, Kidney and Urologic Diseases Using Biosamples from the NIDDK Repository (R01)" has been published, see http://grants1.nih.gov/grants/guide/pa-files/PAR-13-228.html.

    Applicants should also note that the NIDDK PAR-13-228 does not require prior approval from TrialNet, (such as DPT-1 samples). Applicants are advised to use PAR-12-265 for studies requiring TrialNet samples, and to apply to TrialNet for access 6 weeks prior to grant deadlines. Contact Lisa Spain with any questions.

  • Research Using Biosamples from Selected Type 1 Diabetes Clinical Studies (DP3) (PAR-14-065)

NIH general announcement for all investigator-initiated research:


TN-01 Pathway to Prevention (Natural History)


TN-05 Anti-CD20 (Retuximab)

TN-08 GAD New Onset

TN-09 CTLA-4 Ig (Abatacept)

TN-14 Anti-IL1 Beta (Canakinumab)